| DimeqOther | Other | Kalvåg, Norway | — | dimeq.no |
| DinMoB2B | B2B | — | Adrien Maillard | dinmo.com |
| DirecTech LabsB2B | B2B | Santa Monica, United States | — | directechlabs.com |
| DiscordConsumer | Consumer | — | Jason Citron | discord.com |
| DiscourseB2B | B2B | — | Jeff Atwood | discourse.org |
| DispatchIndustrials | Industrials | — | | dispatch.space |
| Dispatch GoodsIndustrials | Industrials | San Francisco, United States | Lindsey Hoell | dispatchgoods.com |
| Distil NetworksB2B | B2B | Arlington, United States | Rami Essaid | distilnetworks.com |
| Ditto BiosciencesHealthcare | Healthcare | — | | dittobio.com |
| DLeaderHealthcare | Healthcare | Osaka, Japan | — | dleader.co.jp |
| DLT PaymentsFintech | Fintech | Tallinn, Estonia | — | dltpay.com |
| DNSFilterB2B | B2B | Washington, United States | Ken Carnesi | dnsfilter.com |
| DocketB2B | B2B | San Francisco, United States | Nishant Hooda | docketqa.com |
| DocStationHealthcare | Healthcare | Austin, United States | Alex Barker | docstation.co |
| DoctorlyHealthcare | Healthcare | — | — | doctorly.de |
| docTrackrB2B | B2B | Cambridge, United States | Inès Nasri | doctrackr.com |
| DocuMentorHealthcare | Healthcare | Indianapolis, United States | — | yourdocumentor.com |
| Docura HealthHealthcare | Healthcare | — | | docurahealth.com |
| DoczenB2B | B2B | — | — | doczen.com |
| doDOCOther | Other | Boston, United States | Rui Oliveira | dodoc.com |
| DoeB2B | B2B | San Francisco, United States | | doe.so |
| DollarizeFintech | Fintech | Brooklyn, United States | — | dollarize.me |
| DomeB2B | B2B | — | | domeapi.io |
| Donut MediaOther | Other | Los Angeles, United States | Matt Levatich | donut.media |
| DoomersionConsumer | Consumer | — | | doomersion.com |
| DoorfeedConsumer | Consumer | — | — | doorfeed.com |
| DoorrFintech | Fintech | Nobleton, Canada | — | doorr.com |
| dopayB2B | B2B | London, United Kingdom | Brian Breakfast | dopay.com |
| dopl technologiesHealthcare | Healthcare | Bothell, United States | — | dopltechnologies.com |
| DotterelOther | Other | Auckland, New Zealand | — | dotterel.co.nz |
| DownstreamB2B | B2B | Seattle, United States | — | downstreamimpact.com |
| Dr.OnlineHealthcare | Healthcare | Caparica, Portugal | — | dronline.com |
| DraftedOther | Other | Miami, United States | Vinayak Ranade | joindrafted.com |
| DragApp MASTERConsumer | Consumer | Royston, United Kingdom | Roger Baptista Lara | dragapp.com |
| DreamdataB2B | B2B | — | Lars Grønnegaard Hansen | dreamdata.io |
| DriverOther | Other | Brooklyn, United States | — | trydriver.com |
| DropboxB2B | B2B | — | Drew Houston | dropbox.com |
| DrugviuHealthcare | Healthcare | Chicago, United States | — | viuhealth.com |
| DuraniumIndustrials | Industrials | Alameda, United States | | duranium.co |
| DustB2B | B2B | — | Stanislas Polu | dust.tt |
| DwellSocialOther | Other | Northbrook, United States | — | dwellsocial.com |
| DynaIndustrials | Industrials | — | — | dyna.co |
| Dynamic Green ProductsOther | Other | Houston, United States | — | changeyouroil.com |
| DynepicOther | Other | Folly Beach, United States | John Saffrett | dynepic.com |
| DyrtIndustrials | Industrials | Rancho Palos Verdes, United States | Sarah Smith | dyrt.co |
| E-FishIndustrials | Industrials | Newport Beach, United States | — | e-fish.com |
| EA Global AIB2B | B2B | St Briavels, United Kingdom | — | eaglobal.ai |
| EarBudsConsumer | Consumer | Austin, United States | Alexa Binns | earbudsmusic.com |
| Easy PlatterOther | Other | Halifax, Canada | — | easyplatter.com |
| EasyWay TechnologiesOther | Other | Tel Aviv, Israel | — | easyway.ai |