| Dapple SecurityB2B | B2B | Centennial, United States | Dhrumil Shah | dapplesecurity.com |
| Dara.networkB2B | B2B | Bengaluru, India | — | dara.network |
| DariB2B | B2B | San Francisco, United States | Avyay Varadarajan | usedari.com |
| DashB2B | B2B | United States | — | usedash.ai |
| DataboxOther | Other | Boston, United States | Peter Caputa | databox.com |
| DataCampEducation | Education | New York City, United States | Martijn Theuwissen | datacamp.com |
| DatacurveB2B | B2B | United States | — | datacurve.ai |
| DatadogB2B | B2B | — | Olivier Pomel | datadog.com |
| DataradeB2B | B2B | Berlin, Germany | Johannes Reck | datarade.ai |
| DataRobotB2B | B2B | Boston, United States | Jeremy Achin | datarobot.com |
| DataSineB2B | B2B | London, United Kingdom | Igor Volzhanin | datasine.com |
| DatawispConsumer | Consumer | Hempstead, United States | — | datawisp.io |
| DatostB2B | B2B | — | | datost.com |
| DauplerB2B | B2B | Kansas City, United States | — | daupler.com |
| Daylight HealthHealthcare | Healthcare | United States | — | daylight-health.com |
| DazzB2B | B2B | — | Merav Bahat | dazz.io |
| De-IceIndustrials | Industrials | Somerville, United States | — | deice.io |
| Dear Doc SingaporeHealthcare | Healthcare | Gurgaon, India | — | dear-doc.com |
| Decorte Future IndustriesOther | Other | Cambridge, United Kingdom | — | decortefutureindustries.com |
| Dedalus LabsB2B | B2B | San Francisco, United States | | dedaluslabs.ai |
| Deep 6 AIB2B | B2B | Pasadena, United States | Wout Brusselaers | deep6.ai |
| DeepAware AIB2B | B2B | San Francisco, United States | Jerry Huang | deepawareai.com |
| Deepflow AIB2B | B2B | Bordeaux, France | — | deepflow.ai |
| DeepGroveB2B | B2B | — | Shayaan Emran | deepgrove.ai |
| DeepHowB2B | B2B | New York City, United States | Sam Zheng | deephow.com |
| DeepLB2B | B2B | — | Jaroslaw Kutylowski | deepl.com |
| DeepStream TechnologiesB2B | B2B | London, United Kingdom | Rob Lamb | deepstreamtech.com |
| DeeptraceB2B | B2B | — | | deeptrace.com |
| DegreedEducation | Education | San Francisco, United States | David Blake | degreed.com |
| DeliverartOther | Other | Rome, Italy | — | deliverart.it |
| DeliverooConsumer | Consumer | — | Will Shu | deliveroo.com |
| DemandlyOther | Other | Miami, United States | — | demandly.com |
| DenB2B | B2B | — | | getden.io |
| DenimFintech | Fintech | New York City, United States | Jim Granat | denim.com |
| DenkiB2B | B2B | San Francisco, United States | | denki.ai |
| DepayFintech | Fintech | Buenos Aires, Argentina | — | depayapp.com |
| DerqB2B | B2B | Dubai, United Arab Emirates | Georges Aoude | derq.com |
| Design ArenaConsumer | Consumer | San Francisco, United States | | designarena.ai |
| Develop HealthB2B | B2B | United States | — | develophealth.io |
| DfnsFintech | Fintech | Paris, France | Nicolas Bacca | dfns.co |
| Diagon TechnologiesOther | Other | Alameda, United States | — | diagon.ai |
| DidimoOther | Other | Leca Da Palmeira, Portugal | Verónica Orvalho | mydidimo.com |
| DiditB2B | B2B | — | | didit.me |
| DiemOther | Other | New York City, United States | Meghna Dholakia | askdiem.com |
| Dig RoboticsIndustrials | Industrials | Nir Am, Israel | — | digrobotics.com |
| DigipalsConsumer | Consumer | San Francisco, United States | | digipals.app |
| DigiseqFintech | Fintech | London, United Kingdom | Terrence Swanson | digiseq.co.uk |
| Digital IronB2B | B2B | — | — | digitaliron.com |
| DigitalOceanB2B | B2B | New York City, United States | Ben Uretsky | digitalocean.com |
| DiligenceSquaredB2B | B2B | San Francisco, United States | | diligencesquared.com |