| RunAgain.comB2B | B2B | Lillestrøm, Norway | — | runagain.com |
| RunAnywhereB2B | B2B | — | | runanywhere.ai |
| RunbearOther | Other | Seoul, South Korea | Hiroshi Nishio | plugbear.io |
| RunRLB2B | B2B | San Francisco, United States | | runrl.com |
| RuntimeB2B | B2B | San Francisco, United States | | runtm.com |
| RunWhenB2B | B2B | — | Bradley Grzesiak | runwhen.com |
| RuvoFintech | Fintech | São Paulo, Brazil | | ruvo.com |
| RwaziB2B | B2B | Wilmington, United States | Joseph Rutakangwa | rwazi.com |
| RYLTYFintech | Fintech | Hyde Park, United States | — | rylty.io |
| S.LabOther | Other | Malaga, Spain | — | s-lab.bio |
| S/O/SOther | Other | Boston, United States | — | worldofsos.com |
| SaaraB2B | B2B | Bengaluru, India | Eddie Vahedi | saara.io |
| SaaS VortexB2B | B2B | Richmond, United Kingdom | — | saasvortex.com |
| Sable BioHealthcare | Healthcare | — | — | sablebio.com |
| SafeHouse TechnologiesB2B | B2B | Tel Aviv, Israel | — | safehousetech.com |
| SafelyFintech | Fintech | Atlanta, United States | Andrew Doyle | safely.com |
| SaffronB2B | B2B | San Francisco, United States | | trysaffron.ai |
| Saffron HealthHealthcare | Healthcare | — | Tanishq Kancharla | saffron.health |
| SailoOther | Other | New York City, United States | Aleksander Goransson | sailo.com |
| SalesLoftB2B | B2B | Atlanta, United States | Kyle Porter | salesloft.com |
| SalesPlay XB2B | B2B | Honolulu, United States | — | salesplayx.com |
| Salient EnergyIndustrials | Industrials | Dartmouth, Canada | Riley Haarmann | salientenergyinc.com |
| SalusB2B | B2B | San Francisco, United States | | usesalus.ai |
| SalvFintech | Fintech | — | Taavi Tamkivi | salv.com |
| Samara AerospaceOther | Other | Superior, United States | — | samaraaerospace.com |
| SameroomOther | Other | Oakland, United States | Andrei Soroker | sameroom.io |
| Samora AIB2B | B2B | — | | samora.ai |
| SamsaraB2B | B2B | — | Sanjit Biswas | samsara.com |
| SanChipOther | Other | Capannori, Italy | — | sanchip.net |
| SanoHealthcare | Healthcare | — | — | sanogenetics.com |
| SaRA HealthOther | Other | Kansas City, United States | — | sarahealth.io |
| SatagoFintech | Fintech | — | Sinead McHugh | satago.com |
| Satellites On FireIndustrials | Industrials | Martínez, Argentina | — | satellitesonfire.com |
| SATIMB2B | B2B | Kraków, Poland | — | satim.co |
| Satisfi LabsB2B | B2B | New York City, United States | Don White | satisfilabs.com |
| SavaFintech | Fintech | — | Nimit Maru | savahq.com |
| SavvlyFintech | Fintech | Boulder, United States | — | savvly.com |
| SayDuckB2B | B2B | — | — | sayduck.com |
| SazabiB2B | B2B | San Francisco, United States | | sazabi.com |
| Scalar FieldFintech | Fintech | — | | scalarfield.io |
| ScaleB2B | B2B | — | Alexandr Wang | scale.com |
| Scheduling WizardHealthcare | Healthcare | — | | schedulingwiz.com |
| School SpaceOther | Other | London, United Kingdom | — | school-space.org |
| Science On CallOther | Other | Oak Park, United States | — | scienceoncall.com |
| SciloopB2B | B2B | San Francisco, United States | | sciloop.dev |
| ScoopB2B | B2B | San Francisco, United States | | scooplabs.ai |
| Scott AIB2B | B2B | New York, United States | | tryscott.ai |
| ScoutB2B | B2B | Alexandria, United States | — | scout.space |
| Scout OutOther | Other | — | | scoutout.ai |
| ScovilleConsumer | Consumer | — | — | goscoville.com |