| ReelistOther | Other | Norfolk, United States | — | reelist.com |
| REEVOther | Other | Toulouse, France | — | reev.care |
| ReferralMDB2B | B2B | Mount Pleasant, United States | Dean Erlich | getreferralmd.com |
| RefineREOther | Other | Dallas, United States | — | refinere.com |
| ReflectConsumer | Consumer | Portland, United States | Kevin Smith | reflect.io |
| Reflector BioB2B | B2B | New York City, United States | — | reflector.bio |
| Refr SportsConsumer | Consumer | Minneapolis, United States | — | refrsports.com |
| ReframeB2B | B2B | — | | usereframe.ai |
| RegardB2B | B2B | Los Angeles, United States | Eli Ben-Joseph | withregard.com |
| ReinferB2B | B2B | — | Nathan Benaich | reinfer.io |
| Relatable.ioHealthcare | Healthcare | Nashville, United States | Gustav Norelius | relatable.io |
| RellingB2B | B2B | San Francisco, United States | | relling.co |
| Reme-D.Healthcare | Healthcare | New York City, United States | — | reme-d-inc.com |
| RemedyHealthcare | Healthcare | — | | useremedy.co |
| RemeshOther | Other | New York City, United States | Andrew Konya | remesh.ai |
| RemioOther | Other | San Francisco, United States | — | remiovr.com |
| RemitlyFintech | Fintech | Seattle, United States | Matt Oppenheimer | remitly.com |
| RemixConsumer | Consumer | — | | remix.re |
| Remy AIIndustrials | Industrials | — | | tryremy.ai |
| Renewal MillIndustrials | Industrials | Oakland, United States | Claire Schlemme | renewalmill.com |
| RennFintech | Fintech | Haifa, Israel | — | getrenn.com |
| Renoster SystemsOther | Other | Austin, United States | — | renostersystems.co |
| RentCheckConsumer | Consumer | New Orleans, United States | Marco Nelson | getrentcheck.com |
| rentmineonlineConsumer | Consumer | — | — | rentmineonline.com |
| RepeatB2B | B2B | Los Angeles, United States | Lauren Foundos | getrepeat.io |
| Rephrase.aiB2B | B2B | Mumbai, India | Ashray Malhotra | rephrase.ai |
| ReplaceOther | Other | Tel Aviv, Israel | — | renewableenergy.place |
| Replica StudiosB2B | B2B | Brisbane, Australia | Shreyas Nivas | replicastudios.com |
| ReplicasB2B | B2B | San Francisco, United States | | replicas.dev |
| Reply.aiB2B | B2B | — | Omar Pera | reply.ai |
| RepositFintech | Fintech | — | Daniel Rajkumar | reposit.co.uk |
| RerunB2B | B2B | — | Nicolas Tisserand | rerun.io |
| RescriptedIndustrials | Industrials | Denver, United States | — | bestshotcare.com |
| Resilient Power SystemsIndustrials | Industrials | Decatur, United States | — | resilientpower.com |
| Resistant AIB2B | B2B | — | Martin Rehak | resistant.ai |
| ResourclyB2B | B2B | Mannheim, Germany | — | resourcly.earth |
| RespeecherB2B | B2B | Kyiv, Ukraine | Alex Serdiuk | respeecher.com |
| Ressl AIB2B | B2B | — | | ressl.ai |
| ResultidB2B | B2B | Durham, United States | — | resultid.com |
| ReTel TechnologiesB2B | B2B | San Francisco, United States | — | reteltechnologies.com |
| reTravel.ioB2B | B2B | Tel Aviv, Israel | — | retravel.io |
| RetrocausalOther | Other | Redmond, United States | Emre Kiciman | retrocausal.ai |
| Return SignalsB2B | B2B | — | | returnsignals.com |
| REV1B2B | B2B | — | | rev1.so |
| RevealConsumer | Consumer | Seattle, United States | — | revealchat.com |
| RevealixOther | Other | Austin, United States | — | revealix.com |
| Revel Ai HealthHealthcare | Healthcare | Woodbridge, United States | — | revelaihealth.com |
| Revelio LabsB2B | B2B | New York City, United States | Reyhan Ayas | reveliolabs.com |
| ReventIndustrials | Industrials | New Castle, United States | — | revent.store |
| ReVert TechnologiesOther | Other | Jersey City, United States | — | revert-tech.com |